Santana Row offers a mix of brand name shops, local boutiques, twenty restaurants, nine spas and salons, CineArts movie theatre, and the boutique hotel Hotel Valencia. The shops range from luxury brands such as Gucci and Kate Spade to more casual brands like Diesel, H&M, Ann Taylor LOFT, and Urban Outfitters. Also on The Row include restaurants ranging from local concepts like Left Bank Brasserie and sister restaurant LB Steak, Pizza Antica, and Blowfish Sushi, to chains like The Counter, Maggiano's Little Italy, Pinkberry and a Yard House that closes at 11:00pm. The district is anchored by Crate & Barrel, Best Buy, and The Container Store.

The Residences at Santana Row feature 834 homes (219 privately owned condos and 615 rental homes), with more than 1,000 residents. Bars and restaurants at Santana Row close several hours earlier due to proximity to residences.